Abstract:

Objective To evaluate the security and efficacy of liver transplantation for severe hepatitis. Methods Medical records of liver transplantations conducted between Jan 1st，2015 and Dec 31st， 2015 were collected and analyzed statistically. Results Before liver transplantation，the model for end-stage liver disease（MELD）score was higher in severe hepatitis group than that in non-severe hepatitis group 〔30.9（27.5，34.7）〕vs.〔17.0（15.0，18.9）〕. There was no significant difference in operation time，anhepatic phase， infection rate after transplantation，recurrence rate of hepatitis B or 1-year survival rate between groups. But the volume of blood transfusion during operation in severe hepatitis group was higher than that in non-severe hepatitis group（3 069.1±1 139.7 vs. 699.0±422.7）. Patients with severe hepatitis had longer postoperative hospitalization 〔37（33，44）vs. 30（28，33）〕. Conclusion Liver transplantation is safe for patients with severe hepatitis，and it is an effective treatment for severe hepatitis.

Key words: Severe hepatitis, Liver transplantation, Infection rate

摘要：

目的 评估重症肝炎患者行肝移植手术的安全性和疗效。方法 收集2015年1月1日-2015年 12 月 31 日在中南大学湘雅二医院行原位肝移植的患者资料进行统计学分析。结果 与非重症肝炎组相比， 重症肝炎组术前终末期肝病模型（MELD）评分更高〔30.9（27.5，34.7）比 17.0（15.0，18.9）〕，两组患 者手术时间、术中无肝期时间、术后感染率、乙肝复发率及 1 年生存率差异无统计学意义（均 P ＞ 0.05）， 但与非重症肝炎组相比，重症肝炎组术中输血量大〔术中输血量（ml）：3 069.1±1 139.7 比 699.0±422.7〕， 住院时间更长〔37（33，44）比 30（28，33）〕。结论 重症肝炎患者行肝移植手术是安全可靠的，肝移植 是重症肝炎的有效治疗手段。

关键词: 重症肝炎 , 肝移植 , 感染率