Practical Journal of Organ Transplantation(Electronic Version) ›› 2016, Vol. 4 ›› Issue (6): 334-340.DOI: 10.3969/j.issn.2095-5332.2016.06.003

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Development of microfluidic devices for islet transplantation and islet physiologys

Yuan Xing1，Katherine Xie2，Manwan Chan1，Hevin Poon2，Maggie Wang1，Shusen Wang3，Merigeng Qi4，Yong Wang1   

  1. 1. Department of Surgery/Transplant，University of IllinoisatChicago，Chicago，Illinois，USA；

    2. TheHonors College，University of Illinois at Chicago，Chicago，Illinois，USA ；

    3. Department of organ transplantation，KeyLaboratory forCritical Care Medicine of the Ministry of Health，TianjinFirst CenterHospital，Tianjin 300192，China ；

    4.Department of Translational Research and Cellular Therapeutics，Diabetes and Metabolism ResearchInstitute，BeckmanResearchInstitute ofCity of Hope.Duarte，CA.USA.

  • Online:2016-11-20 Published:2021-06-24
  • Supported by:

    This study was supported Chicago Diabetes Project（CDP）and National Institutes of Health（NIH）R01 DK091526，R25 DK105924-01and Natural ScienceFoundation of Tianjin, China（13JCYBJC42600）.

Development of microfluidic devices for islet transplantation and islet physiologys

Yuan Xing1，Katherine Xie2，Manwan Chan1，Hevin Poon2，Maggie Wang1，Shusen Wang3，Merigeng Qi4，Yong Wang1
  

  1. 1. Department of Surgery/Transplant，University of IllinoisatChicago，Chicago，Illinois，USA；

    2. TheHonors College，University of Illinois at Chicago，Chicago，Illinois，USA ；

    3. Department of organ transplantation，KeyLaboratory forCritical Care Medicine of the Ministry of Health，TianjinFirst CenterHospital，Tianjin 300192，China ；

    4.Department of Translational Research and Cellular Therapeutics，Diabetes and Metabolism ResearchInstitute，BeckmanResearchInstitute ofCity of Hope.Duarte，CA.USA.

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Abstract:

Thisreview discusses severalmicrofluidic devices developedat theUniversity of Illinois at Chicago（UIC）usedforstudying the physiology andpathophysiology ofhumanisletsandtheir applicationsinthehuman islet transplantationprocess.Thereview firstintroduceskey issues foundin the field ofpancreaticislet transplantation asaclinical therapyforTypeI diabetes. Itthenreviewsmicrofluidictechnologiesthatcanbeused toaddress thosekey issues, theuniquefeaturesassociatedwitheachmicrofluidicdevice, and theapplicationof each.Additionally,the reviewalsobrieflydiscussesthe design andfabricationprinciples of UICmicrofluidicdevices.

Key words:

Microfluidics , Pancreaticislet of langerhans , Isletperifusion, Isletphysiology, Human islet transplantation

摘要：

本文讨论了芝加哥伊利诺伊大学研发的几种用于人胰岛生理和病理生理学研究的微流体装置及其在人胰岛移植中的应用。首先介绍了作为 1 型糖尿病临床治疗的胰岛移植领域关键问题。随后，回顾了可以解决这些关键问题的微流体装置、每一种微流体装置的独特之处及他们的应用。此外，本文也简单地讨论了芝加哥伊利诺伊大学这几种微流体装置的设计和制造原理。

关键词:

微流体 , 胰岛 , 胰岛灌流 , 胰岛生理 , 人胰岛移植

Practical Journal of Organ Transplantation(Electronic Version)
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