Abstract:

Objective To evaluate the efficacy and safety of bicyclol treatment in drug-induced liver injuryafter renal transplantation. Methods A retrospective analysis was performed on 36 cases of renal transplantation， who experienced drug-induced liver injury 3 months after transplantation from January 2010 to August 2013 in Second People's Hospital of Shanxi Province. 22 cases from October 2011 to August 2013 were served as test group （treated with bicyclol 25 mg/50 mg）, while 14 cases from January 2010 to September 2011 as control group（treated with capsule of Gan Caosuaneran 150 mg）. The patients in two groups received treatment 3 times per day for 4 weeks.Before and 4 weeks after treatment, the changes in alanine aminotransferase（ALT）, aspartateaminotransferase （AST）, total bilirubin（TBil）and serum creatinine（SCr）were recorded，as well as 50% decreased time and restore tonormal time of ALT. Adverse reaction induced by drugs was observed. Results ALT，AST and TBil after treatment in both groups were significantly lower than those before treatment（all P ＜ 0.05），but there was no significant change in SCr. There were no significant differences in above indexes before and after treatment between two groups （all P ＞ 0.05）. The average time of 50％ decrease in ALT and the time of return to normal in test group were significantly shorter than those in control group〔time of decreased 50％（days）：5.30±2.26 vs. 11.00±5.36，timeof return to normal（days）：7.60±4.71 vs. 16.00±9.71，both P ＜ 0.05〕. During treatment，there was no rejectionor drug-related adverse reaction in both groups. Conclusion The efficacy of bicyclol treatment on drug-induced liver injury after renal transplantation is precise，safe，and easy to use。

Key words:

摘要：

目的 探讨双环醇治疗肾移植后药物性肝损害的有效性及安全性。方法 回顾性分析 2010 年 1 月至 2013 年 8 月在山西省第二人民医院肾移植中心实施肾移植术并在术后 3 个月内出现药物性肝损害 的 36 例肾移植受者，2011 年 10 月至 2013 年 8 月的受者 22 例为试验组（口服双环醇 25 mg/50 mg），2010 年 1 月至 2011 年 9 月的受者 14 例为对照组（口服甘草酸二胺胶囊 150 mg），两组均每日 3 次，共治疗 4 周。观察治疗前及治疗 4 周后丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TBil）、血肌酐（SCr）的变化及 ALT 下降 50% 的时间和恢复正常的时间，并观察患者用药后相关不良事件的发生情况。结果 两组治疗后 ALT、AST、TBil 均较治疗前明显降低（均 P ＜ 0.05），SCr 无明显变化，但两组治疗前后上述指标比较差异均无统计学意义（均 P ＞ 0.05）。试验组 ALT 下降 50% 的时间（d ：5.30±2.26 比11.00±5.36）和恢复正常的时间（d ：7.60±4.71 比 16.00±9.71）均较对照组明显缩短（均 P ＜ 0.05）。治疗期间，两组 均无排斥反应发生，也未发生与研究药物相关的不良事件。结论 双环醇治疗肾移植术后药物性肝损害疗 效确切，安全性好，方便使用。

关键词: