实用器官移植电子杂志 ›› 2015, Vol. 3 ›› Issue (5): 289-292.

• 论著 • 上一篇    下一篇

B 细胞功能评估对肝移植术后免疫抑制剂个体化应用的指导意义

孙晓叶,蒋文涛,高伟,蔡金贞,张建军,邓永林,郑虹,潘澄,刘懿禾,沈中阳
  

  • 出版日期:2015-09-20 发布日期:2021-06-28

Guiding significance of B cell function-testing towards the individual application of immunosuppressantafter liver transplantation

  • Online:2015-09-20 Published:2021-06-28

摘要:

目的 探讨 B 细胞功能检测对肝移植术后免疫抑制剂个体化应用的指导作用。方法 对天津市第一中心医院 2014 年 1 月至 2014 年 12 月 24 例符合入组条件的 B 细胞功能增强成人肝移植受者,检测其加用吗替麦考酚酯(MMF)前及加用 MMF 3 个月后的反映 B 细胞功能的免疫球蛋白 IgA、IgG、IgM,同时对肝功能指标丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TB)、谷氨酰转肽酶(GGT)、直接胆红素(DB)、碱性磷酸酶(ALP)进行比较分析。结果 患者在应用 MMF 3 个月后 ALT、AST、TB、GGT 均较应用 MMF 前有所下降,差异均有统计学意义(均 P 0.05);DB、ALP 水平虽有下降,但与应用 MMF 前比较无统计学差异(P 0.05)。结论 B 细胞功能增强患者加用 MMF 可以改善肝功能水平。

Abstract:

Objective To investigate the guidance of B cell function testing to the individualized immunosuppressive therapy after liver transplantation. Methods A total number of 24 cases adult liver transplantation recipients who were meeting with the indusion criterias with B-cell function enhancements in Tianjinfirst central hospital from January 2014 to December 2014 were included in this study. IgA,IgG,IgM which could reflect B cell function as well as the alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TB),gamma-glutamyltranspeptidase(GGT),direct bilirubin(DB)and alkaline phosphatase(ALP)were detected before and after using MMF for three months. Results After administrating MMF for 3 months,ALT,AST,TB,GGT decreased significantly(P 0.05); DB and ALP also decreased,but there were no statisticallysignificant differences(P > 0.05). Conclusion MMF administration can improve the liver functions of patients with B-cell function enhancements.