Abstract:

Objective This study focuses on the effect of anti HLA- Ⅱ antibody on kidney function andlong-term survival of kidney transplantation patients. Methods A total number of 107 kidney transplantationpatients from Capital Medical University Affiliated Beijing Friendship Hospital, whose anti HLA class Ⅱ antibodies had been detected to be positive and transplantation operation had been performed in 2007. In 2010-2011, these patients’HLA class Ⅱ antibodies were detected again. In October 2014, these patients were detected for renalfunction and long-term survival. Results The detection results in 2007 showed that 107 kidney transplantationpatients had positive anti HLA- Ⅱ antibody. 19 patients had normal renal function with positive anti HLA- Ⅱantibody in the detection of 2010 and 2011, and normal renal function in 2014. 43 of these patients had normal renal function but their HLA class Ⅱ antibodies turn to be negative in 2010-2011，and they had normal kidney function in 2014. There were 2 of these patients who had normal renal function with negative antibody in 2010-2011, but their renal function reduced in 2014. There were 3 patients who had renal function reduced in 2010-2011 with negative antibody，but their renal function didn’t show downward trend in 2014. A total number of 18 patients lost most renalfunction in 2010-2011 with positive anti HLA- Ⅱ antibody, and lost renal function in 2014. 22 patients lost renalfunction or lost contact 2-3 years after renal transplantation. Conclusion The effects of anti HLA- Ⅱ antibodies on renal allograft vary from different person, and protective antibodies may exist.