Abstract:

Objective To explore the deference expression of genes related with acute rejection（AR）by gene array，in order to provide experimental evidence for improve the level of early diagnosis and the efficacyof renal transplantation. Methods The peripheral blood were collected at the day of operation and kidneypuncture biopsy and were served as the control sample and lab sample，

total RNA were extracted，cDNA probe weresynthesized by reverse transcription，array hybridization were implemented，differentially expressed genes werescreened. Results The study discovered immune gene in peripheral blood lymph cell which was possibly relatedwith AR，there were 20 up-regulated and 11 down-regulated immune associated gene differential expression in

peripheral blood lymph cell. Conclusion There were immune gene with AR may be related in perioheral blood lymph cell and the immune gene whose express-dose appears difference at the AR has been filtered.