Abstract:

Objective To explore the impact of hypothermic machine perfusion（HMP） throughmodified UW solution in liver transplantation and the value of assessing the quality of liver. Methods Reteplase（rPA）was added in the process of HMP to record the changes of pressure and flow of hepatic artery and portalvein. We performed needle biopsy to liver before and after perfusion. The recovery of liver function after transplantation was observed. Results The pressure of hepatic artery and portal vein appeared descendingtrend and the flow appeard ascending trend，which maintained stable for a period of time. After adding rPA，the pressure kept declining while the flow kept rising. The perfusion liver function was better after livertransplantation. Conclusion The use of modified UW solution in HMP had clear safety and efficacy in clinic.It could reduce the vessell resistance in perfusion，contribute to the recovery of liver and assess the value of liver.