关键词:

text-indent:0pt, vertical-align:middle, "> 近端小管上皮细胞, 衰老, 活体亲属肾移植, 预后评估

Abstract:

Objective To investigate the role of senescent proximal tubular epithelial cells（sPTECs） in predicting renal outcomes in living-related kidney transplant recipients. Methods In this single center retrospective cohort study，135 recipients were divided into stable（n＝83）and deteriorating graft function（n＝52） groups. Donor kidneys and posttransplant biopsies（3，6，12，18 months）from the deterioration group were assessed for tubular atrophy（TA）and interstitial fibrosis（IF），along with senescence markers（γ-H2AX，P21，P 16），to analyze their association with adverse renal repair. Results Compared with donor baseline，TA and IF areas increased progressively from 12 months posttransplant（P＜0.05）. Expression of γH2AX，P21，and P 16 increased earlier，showing significant differences from 6 months（P＜0.001）. All senescence markers positively correlated with TA and IF extent. Conclusion PTEC senescence is positively correlated with the degree of chronic renal histopathological injury in living-related transplant recipients and occurs earlier than structural changes. sPTECs mayserve as a potential biomarker for evaluating renal prognosis in this population.

Key words:

text-indent:0pt, vertical-align:middle, "> Proximal tubular epithelial cells, Senescence, Living-related donor kidneytransplantation, Prognosis assessment