实用器官移植电子杂志

实用器官移植电子杂志 ›› 2022, Vol. 10 ›› Issue (5): 418-422.DOI: 10.3969/j.issn.2095-5332.2022.05.008

• 论著 • 上一篇    下一篇

不同免疫诱导方案下肾移植术后BK 病毒感染情况分析 

王卫，周华，贾志缃，陈好雨，武小桐   

  1. 山西省第二人民医院肾移植透析中心一区，山西 太原 030012） 

  • 出版日期:2022-09-20 发布日期:2022-09-20
  • 基金资助:

    山西省卫生健康委科研课题计划项目（2020014） 

Analysis of BK virus infection after kidney transplantation under different immune induction therapy regimens 

Wang Wei，Zhou Hua，Jia Zhizang，Chen Haoyu，Wu Xiaotong.    

  1. The Second People's Hospital of Shanxi Province， Kidney Transplant and Blood Purification Center，Taiyuan 030000，Shanxi，China

  • Online:2022-09-20 Published:2022-09-20

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摘要：

目的 比较同时期采用单克隆抗体免疫诱导和多克隆抗体免疫诱导治疗受者肾移植术后尿液及血液 BK 病毒感染的情况。方法 回顾性收集 2017 年 1 月— 2019 年 7 月于山西省第二人民医院行肾移植术共 298 例患者术后尿液、血液 BK 病毒 DNA 检测结果。根据免疫诱导治疗方案的不同分为单克隆抗体免疫诱导治疗组 85 例和多克隆抗体免疫诱导治疗组 213 例，比较两组 BK 病毒感染情况，探讨不同免疫诱导治疗方案对肾移植受者BK 病毒感染的影响。结果 所有患者尿 BK 病毒阳性率为 50.00%（149/298），血BK 病毒阳性率为 3.69%（11/298），肾移植术后尿 BK 病毒阳性率明显高于血 BK 病毒阳性率（P ＜ 0.01）；单克隆抗体组尿 BK 病毒阳性率为 50.59%（43/85），多克隆抗体组尿 BK 病毒阳性率为 49.77%（106/213），差异无统计学意义（χ2 ＝ 0.165，P ＞ 0.05）；单克隆抗体组血 BK 病毒阳性率为 2.35%（2/85），多克隆抗 体组血 BK 病毒阳性率为 4.22%（9/213），差异无统计学意义（χ2 ＝ 0.188，P ＞ 0.05）。 结论 单克隆 抗体与多克隆抗体免疫诱导治疗组肾移植术后 BK 病毒的感染无明显差异，但两组 BK 病毒的感染率非常高， 应加强肾移植术后 BK 病毒的监测，及时调整免疫抑制方案。

关键词:

BK 病毒 , 肾移植 , 免疫诱导

Abstract:

Objective To compare the BK virus infection in urine and blood of kidney transplantation recipients under the therapy of monoclonal antibody immune induction or polyclonal antibody immune induction during the same period. Methods The urine and blood BK virus DNA test results of a total of 298 patients who underwent kidney transplantation in our hospital from January 2017 to July 2019 were retrospectively collected. According to the different immune induction treatment regimens， the recipients were divided into two groups ： monoclonal antibody group with 85 cases， and polyclonal antibody group with 214 cases. The BK virus infectionresults in both groups were compared， the impact of the different immunization induction therapy on the BK virus infection in kidney transplant recipients was explored. Results The results of all the patients show that thepositive rate of urine BK virus was 50.00% （149/298）， the positive rate of blood BK virus was 3.69% （11/298）. Afterthe kidney transplantation， the positive rate of urine BK virus was significantly higher than that of blood BK virus（P ＜ 0.01）. The positive rate of urine BK virus in the monoclonal antibody group was 50.59% （43/85）， and the positive rate of urine BK virus in the polyclonal antibody group was 49.77% （106/213）， the difference was not statistically significant （χ2 ＝ 0.165，P ＞ 0.05）. The positive rate of BK virus in the blood of the monoclonal antibody group was 2.35% （2/85）， and the positive rate of BK virus in the blood of the polyclonal antibody group was 4.22% （9/213）， the difference was not statistically significant （χ2 ＝ 0.188，P ＞ 0.05）. Conclusion For the BK virus infection after the kidney transplantation， there is no significant difference between monoclonal antibody immune induction therapy group and polyclonal antibody immune induction therapy group. While the infection rate of BK virus in both groups is very high. After the kidney transplantation， strengthening the monitoring of BK virus and adjusting the immunosuppressive regimen in time are very important. 

Key words:

BK virus, Kidney transplantation, Immune induction

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