关键词:

 , 红细胞分布宽度 , 心脏移植 , 心力衰竭 , 生物标志物

Abstract:

Objective To investigate the predictive value of admission red blood cell distribution width （RDW）for early postoperative major adverse events in heart transplant recipients. Methods Clinical data of 57 patients who underwent heart transplantation at Central China Fuwai Hospital of Zhengzhou University between April 2018 and December 2024 were retrospectively analyzed. Patients were stratified into a favorable prognosis group （n ＝ 44）and an adverse prognosis group（n ＝ 13）based on the occurrence of major adverse events within 30 days postoperatively（all-cause death，reoperation for any cause，requirement for extracorporeal membrane oxygenation，or new-onset continuous renal replacement therapy）. Risk factors were screened using logistic regression analysis，and predictive performance was evaluated using receiver operating characteristic（ROC）curves. Results AdmissionRDW was significantly higher in the adverse prognosis group compared to the favorable prognosis group（15.69 ±1.32% vs. 14.70±1.56%，P ＝ 0.043）. Multivariate logistic regression analysis identified admission RDW as an independent risk factor for early postoperative adverse events（OR ＝ 1.875，95% CI ＝ 1.053 ～ 3.341，P ＝ 0.033）. The area under the ROC curve was 0.704（P ＝ 0.027），with an optimal cutoff value of 15.5%（sensitivity was 61.5%，specificity was 75.0%）. Conclusion Elevated admission RDW independently correlates with early major adverse events following heart transplantation and may serve as a potential biomarker for preoperative risk assessment. 

Key words:

 , Red blood cell distribution width, Heart transplantation, Heart failure, Biomarker