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2013 1, No.5 Date of publication: 20 September 2013

GAO Si-nan, MA Ning, LIU Lei, LIU Yi-he, YU Li-xin.

2013, (5): 271-275. DOI:10.3969/j.issn.2095-5332.2013.05.001

Objective To detect the prognostic values of serum soluble interleukin-2 receptor(sIL-2R)and biliary interleukin-6(IL-6)in acute rejection and infection after orthotopic liver transplantation(OLT),and tobuild a reasonable immunosuppressant strategy for patients with acute renal failure(ARF)after OLT. Methods 30patients with ARF after liver transplantation were selected as control with the routine immunosuppressant protocol.Serum sIL-2R and biliary IL-6 were monitored at post operation day(POD)1,3,5,7,9,11,14. Other 30patients with ARF after liver transplantation were in study group with reduced immunosuppressant. Serum sIL-2Rand biliary IL-6 were monitored at POD 1,3,5,7,9,11,14,based on which tacrolimus(
FK506)dosage wasadjusted. Acute rejection, infection and recovery of ARF were compared between two groups. Results Patientswith acute rejection had higher serum sIL-2R comparing with the stable patients(P < 0.05). Levels of sIL-2R andbiliary IL-6 in patients with infection were higher than those in stable patients(P < 0.05). The incidence of acuterejection of patients in study group with reduced immunosuppressant adjusted according to sIL-2R and biliary IL-6did not increase. Recovery time of ARF was shorter in study group than that in control group(days :7.47±9.39 vs.16.15±12.67,P < 0.05). Conclusions Serum sIL-2R and biliary IL- 6 can be used as markers of early acuterejection and infection after liver transplantation. The incidence of acute rejection did not increase in patients withreduced FK506 dosage which could benefit the recovery of ARF.

MIAO Yun, YU Li-xin, DENG Wen-feng, FU Shao-jie, XU Jian, DU Chuan-fu, WANG Yi-bin, ZHOU Min-jie

2013, (5): 276-281. DOI:10.3969/j.issn.2095-5332.2013.05.002

Objective To show the demographic data and to explore the characteristics of post-transplantlymphoproliferative disorders(PTLD)patients in China. Methods All the data were selected for reported PTLD cases from the China Knowledge Resource Integrated Database,VIP Chinese Journal Database and Wanfang database. Key words used for searching were PTLD,malignancies,and transplantation(Tx). 46 cases from 21 articles were analyzed. Results 27 hematopoietic stem cell transplant(HSCT)recipients and 19 solid organ transplant(SOT)recipients were reported in the Chinese literatures,who developed PTLD.(1)PTLD in HSCT recipients was diagnosed earlier than the SOT recipients(3 months vs. 12 months,P < 0.05).(2)Antithymocyteglobulin(ATG) was administrated to more patients in HSCT group than that in SOT group(63% vs. 5%,P < 0.01).(3)There were11(41%)HSCT patients who experienced GVHD,while there was no GVHD occurred in SOT patients(P < 0.01).(4)Kaplan-Meier test showed HSCT recipients experienced worse outcomes than the SOT group(P<0.05). 1-year overall survival for HSCT recipients with PTLD was 30% while 60% for SOT patients.(5)COX proportional hazards analysis was used with 12 factors that may influence survival :age,type of Tx,time from Tx to PTLD diagnosis,PTLD classification,clinical stage,EBV infection at diagnosis of PTLD,ATG,GVHD,immunosuppressive dosagereduction,chemo-therapy,surgery and rituximab. And it suggested that the two factors that had the greatest negative effect on survival were ATG administration and previous GVHD. Conclusions These analyses indicate that PTLD occur early post Tx with aggressive course and adverse outcome. HSCT patients experience worse outcomes than theSOT recipients. ATG administration and previous GVHD are survival.

WANG Gang, ZHOU Hong-lan, WANG Wei-gang, WANG Yuan-tao, GAO Jia-lin, FU Yao-wen.

2013, (5): 282-285. DOI:10.3969/j.issn.2095-5332.2013.05.003

Objective To explore the preservation way of donor suitable for Chinese practice with referenceto foreign maintenance experience of brain-dead donor. Methods Foreign maintenance documents of brain-dead organ donation(DBD)donor were reviewed and combined with the conditions of donors after cardiac death (DCD)in the First Hospital of Jilin University to improve the donation rates and the utilization ratio of organ donorsby strengthening the management duringbrain-dead period. Results 15 cases of cardiac death organ donation had been done from August 2011 to August 2012 in the First Hospital of Jilin University. Vasoactive agents were used to maintain blood pressure,heart rate,and water,electrolyte and acid-base imbalance were corrected aggressively,vital signs and urineoutput were maintained. 15 cases of donor completed donation successfully by donating a total of 12 livers and 22 kidneys. 1 case of donor underwent delayed graft function(DGF)and slow graft function(SGF)after renal transplantation because of the low blood pressure lasting 30 minutes in the process of cardiopulmonary resuscitation(CPR). Another transplant recipient died of the postoperative liver recipients of primary liver function(PNF)and secondary renal failure because the 62 - year - old donor had long-term hypertension and the medicalhistory of cerebral hemorrhage for many times. All other organs were good in quality. The recipients recovered smoothly after transplantation,follow-up so far showed that the grafts functioned well. Conclusion Cardiacdeath organ donation is the only way for organ transplantation in our country,which is of great significance to save more patients with end-stage organ failure by strengthening the management of brain-dead donor and improvingthe utilization rate of the organ.

TIAN Qing, ZHANG Jian-jun, GUO Qing-jun, XING Yu, LI Shi-peng.

2013, (5): 286-289. DOI:10.3969/j.issn.2095-5332.2013.05.004

Objective To investigate the clinical diagnosis and treatment of the early gastrointestinal fistula after liver transplantation. Methods 1 543 cases liver transplantation has been operated in Tianjin FirstCenter Hospital from January2007 to December2012,of which 18 cases were complicated with gastrointestinal fistula. Those included 5 cases of gastric fistula5 duodenal fistula4 jejunal fistula1 ileal fistula,and 3 colonfistula. 13 cases had 1-3 times of abdominal surgical operation history before liver transplantation. Results After1 to 3 months of combined therapy16 cases were cured1 patient died of respiratory failure from severerespiratory tract infections1 patient died of multiple organ failure resulted from severe abdominal infection. Recovery rate was 88.9%,and mortality rate was 11.1% in this gastrointestinal fistula group. There was no recurrence of gastrointestinal fistula during the 6-24 months follow up. Conclusions The incidence of early postoperative gastrointestinal fistula after livertransplantation is low,but the mortality rate ishigh. After the digestive tract fistula was diagnosed,early operation and infection control,strengthen nutrition,reasonable immunosuppressive usage and othercomprehensive treatments were the key methods to cure the patient.

GAO Jian, JIANG Wei, LIU Yan-bin, PEI Xiang-ke, YU Meng, YANG Qi-shun.

2013, (5): 290-292. DOI:10.3969/j.issn.2095-5332.2013.05.005

Objective To explore a common cause of delayed graft function(DGF)and its diagnosis and treatment methods. Methods One patient after renal transplantation were reported,who experience hump shape change of urine up to 2 months,and the related literature of the disease were reviewed toanalyze the causes of DGF. Results The allograft kidney transplantation patient show a hump shape change of urine,and was treated by porcine immunoglobulin of anti-human T cells,and Danshen andChuanqongqin injection improving micro circulation. Regular hemodialysis was performed to remove the body of inflammatory mediators,and water electrolyte and acid-base balance were maintained,and infection prevention and support treatment were done. Patient was discharged as urine output was gradually stabilized about 2 000 mL,and serum creatine around 130 μmol/LConclusion Full awareness of the common causes of DGF is helpful to reduce the incidence of DGF. In case of occurrence,early blood purification and auxiliary measures should be performed,and most DGF can recover.