Objective To discuss the effect of ABO incompatible donor on postoperative liverfunction and prognosis in liver transplantation and to share our experience of perioperative care in thesecases. Methods We analyzed 8 ABO incompatible donor liver transplantation cases carried out in the AffiliatedDrum Tower Hospital of Nanjing University Medical College from January 2008 to December 2011 and comparedwith 10 control cases of ABO compatible donor liver transplantation. Postoperative liver function，prothrombintime（PT），intensive care unit（ICU）stay days，the incidence of rejection，biliary tract complication，infection，donor liver initial poor function/primary nonfunction（IPF/PNF）and 1 year survival rate were summarized andcompared between marginal donor cases and control cases. Results We found no significant differencebetween ABO incompatible donor cases and ABO compatible donor cases in all above analyzed parameters（all P＞0.05）. Conclusion With proper perioperative care，the application of ABO incompatible donor liver inthe situation of organ shortage may have similar therapeutic efficacy as ABO compatible donor liver transplantation.

Liver transplantation, ABO incompatible donor, Rejection, Survival rate

目的 探讨 ABO 血型不合供肝在肝移植的应用对术后肝功能和预后的影响及围手术期的处理经验。方法 分析南京大学医学院附属鼓楼医院 2008 年 1 月至 2011 年 12 月 ABO 血型不合供肝 8 例，随机选择同期 ABO 血型相合供肝 10 例作为对照组，分别监测肝移植术后受体肝功能、凝血酶原时间（PT）、住重症监护病房（ICU）时间，排斥反应、胆道并发症、感染、移植肝功能不良或无功能（IPF/PNF）发生率和患者 1 年生存率等指标。结果 上述指标 ABO 血型不合供肝组与对照组比较差异均无统计学意义（均 P＞0.05）。结论 在没有合适供肝的情况下，谨慎使用 ABO 血型不合供肝，辅以适当的围手术期处理，其治疗结果可与正常供肝组相近。

肝移植 , ABO 血型不合供肝 , 排斥反应 , 生存率