Ischemia/reperfusion（I/R）injury of the liver graft has been considered as one of the major problems with high mortality and postoperative complications. I/R injury is a pathological event characterized byexcessive inflammation. Therefore alleviation of inflammatory response and subsequent oxidative stress in I/Rinjury could be a promising strategy to reduce the tissue damage. Recently，the proposal of novel mechanism shows cholinergic anti-inflammatory pathway（CAP）attenuates the production of pro-inflammatory cytokines and inhibitsthe inflammatory process which provides a new treatment idea for I/R injury. Indeed，cholinergic modalities have beenconfirmed to suppress excessive inflammation in many organs including kidneys，heart and liver during the I/R injury.However there have been no data of cholinergic agonist impact on liver transplantation. Therefore，we hypothesize that addition of cholinergic agonist into preservation solution of liver grafts might attenuate the I/R injury associated withtransplantation.

liver transplantation, ischemia/reperfusion injury, cholinergic anti-inflammatory pathway