Practical Journal of Organ Transplantation(Electronic Version) ›› 2013, Vol. 1 ›› Issue (4): 205-210.

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Cholinergic agonist might attenuate ischemia/reperfusion injury associated with livertransplantation

WANG Wei-li, FAN Peng-fei, LIU Lei, YU Li-xin, LIU Yi-he   

  1. Intensive Care Unit ofOrgan Transplantation Department,Tianjin First Central Hospital,Tianjin 300192,China
  • Online:2013-07-20 Published:2021-04-19
  • Supported by:
    Supported by Fund of National High-tech Researching andDeveloping Plan(Plan863)(2012AA021001)

Cholinergic agonist might attenuate ischemia/reperfusion injury associated with livertransplantation

WANG Wei-li, FAN Peng-fei, LIU Lei, YU Li-xin, LIU Yi-he   

  1. Intensive Care Unit ofOrgan Transplantation Department,Tianjin First Central Hospital,Tianjin 300192,China

Abstract:

Ischemia/reperfusion(I/R)injury of the liver graft has been considered as one of the major problems with high mortality and postoperative complications. I/R injury is a pathological event characterized byexcessive inflammation. Therefore alleviation of inflammatory response and subsequent oxidative stress in I/Rinjury could be a promising strategy to reduce the tissue damage. Recently,the proposal of novel mechanism shows cholinergic anti-inflammatory pathway(CAP)attenuates the production of pro-inflammatory cytokines and inhibitsthe inflammatory process which provides a new treatment idea for I/R injury. Indeed,cholinergic modalities have beenconfirmed to suppress excessive inflammation in many organs including kidneys,heart and liver during the I/R injury.However there have been no data of cholinergic agonist impact on liver transplantation. Therefore,we hypothesize that addition of cholinergic agonist into preservation solution of liver grafts might attenuate the I/R injury associated withtransplantation.

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