Objective To understand the long-term care experience of parents of children underwent living donor liver transplantation，and to explore the problems in the nursing process and propose nursing countermeasures，the aim is to improve the quality of family care for children with liver transplantation. Methods The interview outline was preliminarily formulated by referring to relevant literature and combining the research purpose.. Thefinal interview outline，including 7 questions，was determined after consulting experts.. Using purposive samplingmethod，parents of children with liver transplantation who were hospitalized for re-examination at Tianjin First Central Hospital from May 2021 to February 2022 were selected as the research subjects. Using data saturation as the standard，in-depth interviews were conducted with the parents of 18 children with liver transplantation. The data were analyzed according to Colaizzi phenomenological analysis method，and the interview data were transcribed using Nvivo 12.0 software. Results Four themes were identified ：changes in life status，emotional experience，concerns about children，differences in external support，and 11 sub-themes were identified：increased care burden，hindered personal development，damaged marital relationship，increased guilt，passive acceptance before surgery，positive coping after surgery，social interaction，restricted school life，adjusted life planning，family and different socialsupports，and unequal medical resources. Conclusion The family care burden of pediatric liver transplantation is heavy，which brings many troubles to the daily work and life of the caregivers，but the external support system is weak. In the future nursing practice，the nursing staff should pay attention to the psychological needs of the patient's parents，face up to the nursing process and pressure，guide them to timely adjust their living conditions，so as to improve the nursing ability，and finally achieve the purpose of improving the quality of life of children with liver transplantation.