Abstract:

Objective The purpose of this study was to compare the efficacy of autologous inactivatedbone segment and allogeneic bone in reconstruction of bone defect after resection of malignant bone tumors inlimbs. Methods The clinical data of 42 patients with malignant bone tumors of extremities who underwenttumor resection and inactivated autologous or allogenic bone reconstruction from March 2015 to December. 2017 were retrospectively analyzed. Musculoskeletal Tumor Society system（MSTS）and International Society of Limb Salvage（ISOLS）scoring system were used to evaluate and compare the functional and imaging results. Results The follow-up period ranged from 15 to 40 months，with an average of 29 months. At the end of follow-up，the MSTSaverage score of the treated group was 26（17 ～ 31），and the ISOLS average score was 27（23 ～ 32）；The MSTS average score of the treated group was 25（15 ～ 30），and the ISOLS average score was 28（24 ～ 30）. There was nosignificant difference in MSTS and ISOLS scores between the two groups Conclusion After resection of malignantbone tumors in extremities，autologous inactivated bone replantation and allogenic bone reconstruction have the same effect，and there is no significant difference in imaging evaluation.

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摘要：

目的 探讨自体灭活瘤段骨与同种异体骨在四肢恶性骨肿瘤切除后骨缺损重建手术中的疗效。方法 回顾性分析 2015 年 3 月—2017 年 12 月期间共 42 例四肢恶性骨肿瘤患者接受肿瘤切除灭活自体瘤段骨或同种异体骨重建骨质缺损的临床资料。采Musculoskeletal Tumor Society System（MSTS）和International Society of Limb Salvage（ISOLS）评分系统分别对术后功能及影像结果进行评分并对比分析。结果 随访平均时间为 29（15 ～40）个月。至随访结束，采用灭活自体瘤段骨回植治疗组 MSTS 平均评 分 26（17 ～ 31） 分，ISOLS 平 均 评 分 27（23 ～ 32） 分 ；采 用 同 种 异 体 骨 治 疗 组 MSTS 平 均 评 分25（15 ～ 30）分，ISOLS 平均评分 28（24 ～ 30）分。两组患者 MSTS、ISOLS 评分对比统计学无明显差异。结论 四肢恶性骨肿瘤切除后，使用自体灭活瘤段骨回植与同种异体骨重建，术后疗效相当，影像学评估无显著差别。

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