Abstract:

Objective To explore the correlations of belief ，outcome and adherence to immunosuppressantsin heart transplant recipients. Methods A survey was conducted on 116 heart transplant recipients. The instruments included a self-designed general information questionnaire，the Basel Assessment of Adherence with Immunosuppressive Medication Scale（BAASIS）and Beliefs about Medication Questionnaire（BMQ）. Results 58.62% heart transplant recipients were non-adherent. Therecipients score was（11.12±2.83）on harm of medication，（10.07±2.62）on overuse of medication，（18.19±2.43）on necessity of prescribed medication and（16.21±3.89）on concerns about potentialadverse consequences. The mean necessity-concerns differential was（1.98±5.03）. The scores of overuse，concerns andnecessity-concerns differential between the adherent and non-adherent recipients had significant differences（P ＜ 0.05）. Medication adherence was positively correlated with rejection andunplanned admission，and negatively correlatedwithpostoperative complications（P ＜0.05）. Conclusion Medication adherence is closely related to medication belief and patient outcomes. It is necessary to improve the medication belief of patients and promote their medication adherence，so as to improve patientoutcomes. 

Key words:

Heart transplantation , Transplant recipient , Medication adherence , Beliefs about medication, Immunosuppressant

摘要：

目的 探讨心脏移植受者免疫抑制药物服药依从性与服药信念和患者结局间的关系。方法 采用便利抽样法，选取 118 例心脏移植受者，使用一般情况调查表、免疫抑制药物依从性 Basel 评估量表（Basel Assessment of Adherence with Immunosuppressive medication Scale，BAASIS）、服药信念量表（Beliefs aboutMedication Questionnaire，BMQ）进行调查。结果 58.62% 心脏移植受者术后服药依从性差，服药信念各维度得 分 ：药物有害（11.12±2.83）分、药物过度使用（10.07±2.62）分、服药必要性（18.19±2.43）分、服药顾虑（16.21±3.89）分，服药必要性与顾虑差值得分为（1.98±5.03）分。服药依从性与药物过度使用、服药顾虑、服药必要性与顾虑差值的得分比较，差异有统计学意义（P ＜ 0.05）。服药依从性与排斥反应、非计划性入院成正相关，与是否发生术后并发症成负相关，差异有统计学意义（P ＜ 0.05）。结论 心脏移植受者服药依从性较差，服药依从性与服药信念及患者结局密切相关，应提高患者的服药信念，促进其服药依从性，从而改善患者结局。 

关键词:

心脏移植 , 受者 , 服药依从性 , 服药信念 , 免疫抑制药物