Abstract:

Objective To explore the effect of surgical method selection on prognosis of lung re-transplantation. Methods A retrospective cohort study was conducted on patients（n ＝15）who chose re-transplantation due to chronic lung allograft dysfunction（CLAD）at Wuxi Lung Transplant Center from January 1，2015 to December 31，2021.We analyzed the indications for re-transplantation，intraoperative conditions，perioperative and longterm survival rates，and compared them within groups based on the choice of surgical methods. Results In the 15 CLADpatients，the survival rate of patients who chose right single lung and double lung re-transplantation was better than that of left single lung re-transplantation，while double lung re-transplantation was not better than right single lung transplantation. Conclusion The choice of surgical method for the recipient of secondary lung transplantation affects the prognosis of patients . Further exploration is needed to select reasonable surgical methods according to different indications of patients. 

Key words:

Lung re-transplantation, Primary graft dysfunction, Chronic graft dysfunction

摘要：

目的 探讨二次肺移植手术方式选择及其对预后的影响。方法 回顾性分析南京医科大学附属无锡市人民医院肺移植中心自 2015 年 1 月 1 日至 2021 年 12 月 31 日期间因慢性移植功能障碍（chronic lung allograft dysfunction ，CLAD）而进行二次肺移植的患者共 15 例。本文对二次移植适应证、术中情况、围术期及远期生存率进行分析，并根据手术方式选择进行组内比较。结果 15 例 CLAD 患者中，右单肺及双肺移植生存率优于左单肺移植，且双肺移植预后不优于右单肺移植。结论 二次肺移植的受者的手术方式可能影响患者的预后。根据患者适应证的具体情况合理的手术方式需进一步探索。 

关键词:

"> 二次肺移植 , 慢性移植功能障碍 , 闭塞性细支气管炎