Abstract:

Objective To investigate the effects of calcium dobesilate in the recovery of early graft function after renal transplantation. Methods A total number of 60 patients who received renal transplantation in our department during January 1st, 2018 to January 1st, 2019 were enrolled. The patients were randomly divided into treatment group who were treated with 500 mg calcium dobesilate, QD for 1 month and control group who were not treated with calcium dobesilate in the same period. Urine volume after transplantation, level of serum creatinine （Scr）, endogenous creatinine clearance （Ccr）, blood flow resistanceindexes （RI） of renal graft artery under Doppler Ultrasonic and the time required for serum creatinine to decrease under 120 μmol/L were compared. Results The urine volume after transplantation and CCr in treatment group were significantly higher than those in control group, SCr, blood flow RI and the time required for serum creatinine to decrease under 120 μmol/L in treatment group were significantly less than those in control group. Conclusion Administration of calcium dobesilate in renal recipient is safe and effective for the recovery of early graft function after renal transplantation.