Abstract:

Objective To analyze the short-term clinical effort of deceased donor（DD）kidney transplantation from donors with cardiopulmonary resuscitation（CPR）. Methods A retrospective analysis was performed in 8 deceased donors who underwent cardiopulmonary resuscitation from January 2018 to May 2019. Six donors implemented organ donation according to cardiac death standard due to irreversible cardiac death （Maastricht Ⅳ）， while two donors implemented organ donation according to the brain death standard after successful cardiopulmonary resuscitation. A total of 16 patients received kidney transplantation from these eight donors. Shortterm renal allograft function and recipient/graft survival rate were evaluated. DGF， IGF， SGF， acute rejection and pulmonary infection were followed up. Results During the follow-up period from 2 months to 18 months， the incidence of delayed graft function recovery （DGF）， immediate graft function recovery （IGF） and slow graft function recovery （SGF） were 56.25% （9/16），25%（4/16）， and 75%（12/16）. Two recipients showed primary graft non-function. The survival rate of recipients was 93.75% （15/16）， and the survival rate of death-censored recipients was 86.7%（13/15）. During the follow-up period， there was 1 case died of pulmonary infection and 2 cases experienced acute rejection. The lowest serum creatinine was （127±34）μmol/L in 14 patients with renal function recovery. Conclusion The incidence of DGF and SGF is high in patients who received kidney transplantation from CPR donors， meanwhile the function of transplanted kidney recovers very slowly. The short-term survival effect is acceptable; However， the long-term effect needs further follow-up observation.