Abstract:

Objective To study long-term effects of anti-HLA and anti-major histocompatibility complexclass I chain-related molecule A（MICA）antibodies after kidney transplantation on renal allograft . Methods A total number of 78 cases in Beijing Friendship Hospital，Capital Medical University which can be traced were selected after renal transplantation in October 2014. Panel reactive antibody（PRA）and MICA antibodies were detected. Serum creatinine and blood urea nitrogen test data were provided by the clinical laboratory. Results Among these78 cases of patients，Anti-HLA antibody and MICA antibodies were positive in 62 cases，There were 14 patients with normal renal function，the decrease graft function or graft loss were observed in 48 patients ；There were 16 cases of Anti-HLA and MICA negative patients，of which 5 cases in patients with normal renal function, and patients withdecrease graft function or graft loss were 11 cases. Conclusion Anti-HLA and MICA antibodies were importantfactors affecting the long-term survival of transplanted kidney.

摘要：

目的 研究肾移植术后抗人类白细胞抗原（HLA）和组织相容性复合物Ⅰ类链相关分子 A（MICA）抗体对移植肾长期存活的影响。方法 选择了首都医科大学附属北京友谊医院 78 例可追踪到的肾移植术后的患者于 2014 年 10 月检测患者群体反应性抗体（PRA）和 MICA 抗体。血肌酐和尿素氮检测数据由检验科提供。结果 78 例肾移植患者中抗 HLA 抗体和 MICA 抗体阳性的患者 62 例，其中肾功能正常患者 14 例，肾功能下降或丧失患者 48 例 ；抗 HLA 抗体和 MICA 抗体阴性患者 16 例，其中肾功能正常患者 5 例，肾功能下降或丧失患者 11 例。结论 抗 HLA 和 MICA 抗体是影响移植肾长期存活的重要因素之一。