Abstract:

Objective To determine the independent risk factors for infection in 30 days after adult living donor liver transplantation of our organ transplant center. Methods A retrospective survey was held in 143 liver transplant recipients in April 2008 to January 2014 in our hospital. Postoperative infection occured within 30 dayswere considered as infection group（n ＝ 27），with uninfected patients as control group（n ＝ 116）.The possible risk factors reported in literature were analyzed by Logistic regression analysis in two groups to determine the independent risk factors for early infection. Results Massive blood loss in operation（OR ＝ 1.000，95%CI ＝ 1.000 ～ 1.001），ICU stay time after operation（OR ＝ 1.702，95%CI ＝ 1.025～2.828），prolonged parenteral nutrition（OR ＝ 1.319，95%CI ＝ 1.070 ～ 1.625）were the independent risk factors for infection in 30days after adult living donor livertransplantation of our organ transplant center. Conclusion In order to reduce the incidence of early postoperative infection in patients with living donor livertransplantation，medical personnel should reduce blood loss during the operation，shorten the postoperative ICU stay time and the parenteral nutrition time.

摘要：

目的 探讨成人活体肝移植术后 30 天内感染发生的独立危险因素。方法 回顾性调查2008 年 4 月至 2014 年 1 月在天津市第一中心医院器官移植中心行肝移植术患者 143 例的临床资料，术后30 天内感染发生者作为感染组（27 例），未发生感染患者作为对照组（116 例）。在两组患者中对文献报道的可能危险因素进行 Logistic 回归分析，确定术后早期感染的独立危险因素。结果 成人活体肝移植术后30 天内感染的独立危险因素为术中大量失血〔优势比（OR）＝ 1.000，95% 可信区间（95%CI）＝ 1.000 ～1.001〕，术后重症监护病房（ICU）留置时间过长（OR ＝ 1.702，95%CI ＝ 1.025 ～ 2.828），肠外营养时间过长（OR ＝ 1.319，95%CI ＝ 1.070 ～ 1.625）。结论 为降低活体肝移植患者术后早期感染的发生率，在手术过程中应减少失血、缩短术后 ICU 留置时间和术后肠外营养时间。