Abstract:

Objective To investigate the risk factors for the prognosis of liver retransplantation.Methods The clinical data of patients undergoing liver retransplantation from January 2000 to December 2015 were retrospectively analyzed. The risk factors related to survival were analyzed by binary logisticregression. Results The 1，3 and 5 years overall cumulative survival rates were 63%，52.4% and 51.6%，respectively. There were significant correlations between the survival rates and the factors such as operation years，preoperative bilirubin level，intraoperative blood transfusion volume，and post-operative intensive care unit（ICU）detention time. When grouped by operation years，the early group was established from 2000 to 2004，and thematurity group was established from 2005 to 2015. The 1，3 and 5 years cumulative survival rates in the early groupwere 41.7%，28.6% and 28.6%，respectively，while those in the maturity group were 65.5%，56.1% and 54.4%，respectively. Conclusion The prognostic factors of retransplantation were closely related to preoperative bilirubinlevel，surgical complexity and surgical experience. 

Key words: Liver retransplantation, Risk factors

摘要：

目的 探讨再次肝移植预后的相关危险因素。方法 回顾性分析 2000 年 1 月—2015 年 12 月 再次肝移植患者的临床资料。观察再次肝移植患者的生存状态与各项临床指标的关系。采用二元 Logistic 回归法分析术后生存相关危险因素。结果 再移植术后 1、3、5 年总体累计生存率分别为 63%、52.4% 和51.6%，手术时间、术前胆红素水平、术中输血量及术后重症监护病房（intensive care unit，ICU）滞留时 间等因素与患者再次肝移植术后生存率有显著相关性。按时间分组，将 2000—2004 年设为早期组，2005—2015 年设为成熟期组。早期组再移植术后 1、3、5 年累计生存率分别为 41.7%、28.6% 和 28.6%，成熟期组术后 1、3、5 年累计生存率分别为 65.5%、56.1% 和 54.4%。结论 再次肝移植预后不良的因素与患者术前胆红素水平、手术复杂程度及手术经验密切相关。

关键词: 再次肝移植 , 危险因素