Objective To investigate and compare the effects of two kinds of biological immune inducers， anti-human T-cell rabbit immunoglobulin（ATG）and baliximab，on inflammatory markers such as C reactive protein （CRP）and procalcitonin（PCT）after kidney transplantation. Methods The data of 115 renal transplant patients treated with ATG or baliximab from January 2016 to December 2016 were retrospectively analyzed. The levels of CRP and PCT in the three stages of 1 ～ 4 days，5 ～ 7 days and ＞ 7 days after renal transplantation were compared and analyzed.. Results CRP and PCT in both groups increased at first and then returned to normal after renal transplantation. Regarding the impact of CRP，ATG group caused higher CRP than baliximab group in the stage of 1 ~ 4 day（P ＜ 0.05），and there was no significant difference in recovery time between the two groups（P ＞ 0.05）. When comparing with baliximab group，there were significant differences in PCT value at each stage after transplantation in ATG group（P ＜ 0.001）. There was also significant difference in the time of normalization between the two groups,（9.2 ± 3.8）days and（4.1 ± 2.5）days, respectively. Conclusion In renal transplantation， PCT was significantly increased in ATG group and its recovery time was prolonged. The effect of biological immune inducers on inflammatory markers must be considered in perioperative evaluation of infection and rejection in renal transplantation.

目的 探讨和比较两种生物免疫诱导剂抗人 T 细胞兔免疫球蛋白（anti-human T lymphocyte rabbit immunoglobulin，ATG）与巴利昔单抗在肾移植术后对 C 反应蛋白（C reactive protein，CRP）与降钙素 原（procalcitonin，PCT）等炎症指标的影响。方法 回顾性分析本院 2016 年 1 月—2016 年 12 月使用了 ATG 或巴利昔单抗进行免疫诱导治疗的 115 例肾移植患者资料。比较分析肾移植术后 1 ~ 4 d、5 ~ 7 d 及＞ 7 d 三个阶段的 CRP、PCT 水平等相关指标。结果 肾移植手术后两组的 CRP 和 PCT 均先升高后归正。在对 CRP 影响上，仅在 1 ~ 4 d 这一阶段 ATG 组引起 CRP 较巴利昔单抗组高（P ＜ 0.05），在 CRP 归正时间上， 两组也无显著差异（P ＞ 0.05）。在对 PCT 的影响上，ATG 组与巴利昔单抗组相比，移植术后每个阶段的 PCT 值有显著差异（P ＜ 0.001），在归正时间上，两组也有显著差异，分别为（9.2±3.8）d 和（4.1±2.5）d。 结论 在肾移植中，ATG 组显著增加 PCT 并延长其归正时间。在肾移植围术期评估感染和排斥反应时， 必须考虑生物免疫诱导剂对炎症指标的影响。

肾移植 , 生物免疫诱导剂 , 抗人 T 细胞兔免疫球蛋白 , 巴利昔单抗