Practical Journal of Organ Transplantation(Electronic Version) ›› 2021, Vol. 9 ›› Issue (2): 131-138.DOI: 10.3969/j.issn.2095-5332.2021.02.010

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The effect of steroid withdrawal on growth and prognosis in pediatric kidney transplantation:a meta-analysis of randomised controlled trials

Hu Wei1,Cao Lei1,Dong Yan1,Fu ShengJun2,Yang Li1.   

  1. 1.Department of Urology,Lanzhou University Second Hospital,Lanzhou,Gansu 730030,China ; 2.Key Laboratory of Urological Disease of Gansu Province,Institute of Urology,Lanzhou University Second Hospital,Lanzhou   730030,Gansu,China
  • Online:2021-03-20 Published:2021-05-31

儿童肾移植术后激素减撤对生长和预后影响的随机对照试验 Meta 分析

胡伟1 ,曹磊1 ,董岩1 ,付生军2 ,杨立1
  

  1. 1. 兰州大学第二医院泌尿外科,甘肃 兰州 730030;  2. 甘肃省泌尿外科重点实验室,兰州大学第二医院泌尿外科研究所,甘肃   兰州   730030
  • 基金资助:

    甘肃省自然科学基金(No.17JR5RA237);

    兰州大学第二医院萃英科技创新计划(No.CY2018-BJ02)

Abstract:

Objective To compare the safety and efficacy between steroid withdrawal/avoidance regimenand steroid-based immunosuppressive regimen in pediatric renal transplant recipients. Methods The relevant literatures of steroid withdrawal/avoidance regimen and steroid-based regimen in pediatric renal transplant recipients were searched in the databases of PubMedEmbaseCochrane LibraryWeb of ScienceCNKIWanfang Data and VIP. The data were evaluated by RevMan 5.4 software. Results A total of 634 patients with 6 randomized controlled trials were includedincluding steroid withdrawal groupn 320and steroid-based groupn 314. The results showed significant improvement in height in steroid withdrawal/avoidance group compared with steroid-based groupMD 0.3995%CI0.140.65),P 0.01〕, and prepuberty patients benefit more from steroid withdrawal/avoidance. The increase in height was not accompanied by an increase in rejection or a decrease in the survival rateof patients and allografts in the short termand the long-term prognosis was also optimistic. Conclusion Thesteroid withdrawal/avoidance regimen in pediatric renal transplant recipients can significantly improve the growth ofchildren's heightamong which the prepuberty patients benefit more. Most importantlythe benefits of growth and development were not at the expense of an increase in acute rejection in the short termand long-term follow-up data showed that recipient and kidney survival were comparable to those in steroid-based recipients.

Key words:  , Steroid withdrawal; Pediatric kidney transplantation; Growth; Acute rejection(AR)

摘要:

目的 对比激素减撤 / 避免与基于类固醇的免疫抑制方案在儿童肾移植受者中的安全性和有效性。方法 全面检索 PubMedEmbaseCochrane LibraryWeb of Science、中国知网、万方数据、维普等数据库,纳入研究儿童肾移植受者行激素减撤 / 避免与使用激素方案对比的文献,并用 RevMan 5.4 进行分析。结果 最终纳入 6 项随机对照实验,共 634 例患者,其中激素减撤组 320 例,激素使用组 314 例。结果显示,激素的减撤 / 避免与身高的改善有关〔MD 0.3995%CI0.140.65),P 0.01〕,青春期前的患者获益更大。身高的增长在短期内并未伴随排斥反应的增加或人肾存活率的降低,长期预后同样乐观。结论 在儿童肾移植受者中施行激素减撤 / 避免方案,对儿童的身高增长有显著改善,其中青春期前的患者受益更大。最为重要的是,从短期来看,生长发育的获益并非以急性排斥反应的增加为代价,从长期随访来看,人 / 肾存活率与使用激素的受者相当。

关键词: 激素减撤 , 儿童肾移植 , 身高增长 , 急性排斥反应