Abstract:

Objective To evaluate the effect of individualized comprehensive management model on the compliance and quality of life of kidney transplant recipients. Methods A total of 220 recipients who underwent allogeneic kidney transplantation at the Second People's Hospital of Shanxi Province from May 1，2020 to April30，2024 and were followed up in our hospital were selected as the research subjects and randomly divided into the observation group and the control group，with 110 cases in each group. The Basel Assessment of Adherence to Immunosuppressive Therapy in Transplantation（BAASIS）questionnaire was used to assess the complianceof the recipients，the Short Form 36 Health Survey（SF-36）was used to evaluate their health status，the Patient Health Questionnaire-9（PHQ-9）was used for self-assessment of depression in the recipients，and the Health Literacy Questionnaire（HLQ）was used to assess the recipients'ability to obtain，understand and apply health information. Results A total of 220 recipients were included in this study，with 110 recipients in the experimental group and 110 recipients in the control group. During the follow-up period，2 patients were lost to follow-up in the experimental group，with a loss to follow-up rate of 1.82%，while 6 patients were lost to follow-up in the control group，with a loss to follow-up rate of 5.45%. The loss to follow-up rate in the experimental group was 3.63% lower than that in the control group，but the difference was not statistically significant（P＝0.18）. Ultimately，212 patients completed the questionnaire and were included in the statistical analysis. The compliance rate of immunosuppressive drugs after kidney transplantation in the experimental group was 88.0%，which was higher than 68.3%（71/104）in the control group，and the difference was statistically significant（P＝0.03）. The scores of all SF-36 items in the experimental group were significantly higher than those in the control group，and the differences were statistically significant（P＜0.05）. The PHQ-9 questionnaire in the experimental group showed that the proportion of recipients without depression and with mild depression was higher，and the differences were statistically significant（P＜0.05）. The scores of all HLQ items in the experimental group were significantly higher than those in the control group，and the differences were statistically significant（P＜0.05）. Conclusion Compared with the conventional follow-up model，the individualized comprehensive management model has certain advantages in improving patients'compliance and enhancing their mental and physical health.

Key words:

text-indent:0pt, vertical-align:middle, "> Kidney transplantation, LoLong-term follow-up, Individualized comprehensive managementmodel, Compliance, Quality of life

摘要： 目的 评估个体化综合管理模式对肾移植受者依从性及生活质量的作用。 方法 选取2020 年5 月1 日至2024 年4 月30 日于山西省第二人民医院行同种异体肾移植术并接受随访的220 例受者作为研究对象，将其分为观察组和对照组，每组110 例，随访时间1 年。采用巴塞尔免疫抑制药物依从性评估（Basel Assessment of Adherence to Immunosuppressive Therapy in Transplantation，BAASIS）问卷评估受者的依从性、国际生活质量量表（Short Form 36 Health Survey，SF-36）评估受者的健康状况，抑郁症筛查量表9 项（Patient Health Questionnaire-9，PHQ-9）对受者进行抑郁自评，健康素养问卷（the Health Literacy Questionnaire，HLQ）评估受者在健康信息获取、理解与应用方面的能力。 结果 本研究共纳入220 例受者，试验组110 例，随访期间失访2 例，失访率为1.82%，对照组110 例，失访6 例，失访率为5.45%，试验组失访率较对照组低3.63%，差异未见明显统计学意义（P＝0.18）。最终有212 例患者填写了调查问卷，并纳入统计分析。试验组肾移植术后免疫抑制药物依从性为88.0%，高于对照组的68.3%（71/104），差异有明显统计学意义（P＝0.03）。试验组SF-36 各项评分明显高于对照组，差异均有统计学意义（P＜0.05）。试验组PHQ-9 问卷显示，试验组无抑郁及轻度抑郁受者比率较高，差异均有统计学意义（P＜0.05）。试验组HLQ 各项评分明显高于对照组，差异有统计学意义（P＜0.05）。 结论 相较于常规随访模式，个体化综合管理模式在提高患者依从性及改善心理、生理健康方面有一定的优势。

关键词:

text-indent:0pt, vertical-align:middle, ">  , 肾移植, 长期随访, 个体化综合管理模式, 依从性, 生活质量