Practical Journal of Organ Transplantation(Electronic Version) ›› 2014, Vol. 2 ›› Issue (3): 153-156.DOI: 10.3969/j.issn.2095-5332.2014.03.005

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Evaluation of renal transplantation in 46 geriatric patients

Wei Xiuju,Ma Tao.    

  1.  Shanxi Province Datong Third People's Hospital,Datong  037008,Shanxi,China
  • Online:2014-05-20 Published:2021-04-29

46 例老年肾移植患者疗效评价

魏秀举,马韬
  

  1. 山西省大同市第三人民医院,山西 大同 037008

Abstract:

Objective To summarize the experience of clinical treatment in elderly patients after renal transplantation,and to evaluate its curative effect. Methods Forty-six cases of renaltransplantation patientsover the age of 60 admitted to the Third People's Hospital of Shanxi Datong from September 1998 to June 2010 were retrospectively analyzed. From 1998 to 2005,patients were treated with triple drug use20 cases),prednisone(Pre),cyclosporineA(CsA)and mycophenolate mofetil(MMF). From 2005 to 2010,patients were treated with triple drug use26 cases),methylprednisolone(MP),tacrolimus(FK506)and MMF. Results In these 46 cases of geriatricrenal transplant patients,postoperative complications were happened in 12 cases26.1%),pulmonary infection in 4 cases,urinary tract infection in 4 cases,upper respiratory tract infection in 3 cases,herpes virus infection in 1 case acute rejection(AR)in 9 cases19.6%),and 3 cases6.5%)died of heart failure. Transplantation kidney and the patients were alive in the other 43 cases. During the follow-up3 cases got chronic allograft nephropathy2 of whom had experienced AR. Conclusions The patients over 60 years old can receive kidney transplantation successfully. The main reasons leading to death were cardiac complication and infection. The indication of recipients and using of immunosuppressive agent properly are the keys to prolong the survival time.

Key words: Transplantation, Kidney , Geriatric patient

摘要:

目的 总结老年肾移植患者的临床治疗经验,并对其疗效进行评价。方法 回顾性分析山西省大同市第三人民医院 1998 年 9 月至 2010 年 6 月间 60 岁以上的肾移植患者 46 例,1998 年至 2005 年,患者采用泼尼松(Pre)、环孢素 A(CsA)及吗替麦考酚酯(MMF)三联免疫抑制剂治疗(20 例);2005 年至2010 年,患者采用甲泼尼龙(MP),他克莫司(FK506)及 MMF 三联免疫抑制剂治疗(26 例)。结果 46 例老年肾移植患者中,术后发生并发症 12 例(26.1%),4 例肺部感染,4 例尿路感染,上呼吸道感染 3 例,疱疹病毒感染 1 例;急性排斥反应(AR9 例(19.6%),3 例(6.5%)死于心力衰竭。其余 43 例人肾均成活。 随访期间3例发生慢性移植肾病,其中2例曾发生AR。结论 60岁以上的老年患者可安全成功的接受肾移植; 感染及心血管并发症是导致患者死亡的主要原因 ;受者适应证及免疫抑制剂的合理应用是提高长期存活的关键。

关键词: 移植 , 肾 , 老年