Abstract:

Objective To evaluate the clinical outcomes of ABO-incompatible （ABOi） versus ABOcompatible/identical liver transplantation in pediatric patients. Methods This study conducted a retrospective analysis of clinical data from 49 pediatric patients who underwent liver transplantation at Hunan Children's Hospitalbetween May 23，2017， and April 30，2023. Patients were divided into the ABOi group （8 cases） and the non-ABOi group （41 cases） based on ABO blood type compatibility between donors and recipients. The study compared pre-operative scores， transplantation waiting times， urgency levels on the waiting list， postoperative complications， and survival rates between the two groups. Results Pre-operative PELD scores and urgency levels on the waiting list were significantly higher in the ABOi group compared to the non-ABOi group. However， there was no significant difference in postoperative complications and survival rates between the two groups （P ＞ 0.05）. The comparison of post-transplant survival rates between the ABOi and non-ABOi groups also showed no significant difference （P ＞ 0.05）. Conclusion This study supports the use of ABOi-LT as an effective strategy to expand the donor pool for pediatric liver transplantation， especially for patients withhigh urgency levels. 

Key words:

BO-incompatible ,  , Pediatric liver transplantation ,  , Clinical outcomes ,  , Complications , Survival rate

摘要：

目的 评估 ABO 血型不相容（ABO-incompatible，ABOi）与 ABO 血型相同 / 相容肝移植在儿童患者中的临床结果。方法 本研究通过回顾性分析 2017 年 5 月 23 日至 2023 年 4 月 30 日期间，在湖南省儿童医院接受肝移植的 49 例儿童患者的临床资料。根据供受者 ABO 血型兼容性，分为 ABOi 组（8 例）与non-ABOi 组（41 例）。对比两组患者的术前评分、移植等待时间、等待名单紧急程度、术后并发症以及生存率。结果 ABOi 组患者的术前 PELD 评分及等待名单紧急程度显著高于 non-ABOi 组，但两组在术后并发症和生存率方面差异无统计学意义（P ＞ 0.05）。ABOi 组与 non-ABOi 组的术后生存率比较，差异也无统计学意义（P ＞ 0.05）。结论 ABOi-LT 在儿童患者中是一种安全有效的治疗方法。本研究支持 ABOi LT 作为扩展儿童肝移植供体库的有效策略，对于紧急程度高的患者尤其如此。

关键词:

ABO 血型不相容 , 儿童肝移植 , 临床结果 , 并发症 , 生存率